Pediatric Contact Dermatitis Registry Inaugural Case Data.

TitlePediatric Contact Dermatitis Registry Inaugural Case Data.
Publication TypeJournal Article
Year of Publication2016
AuthorsGoldenberg A, Mousdicas N, Silverberg N, Powell D, Pelletier JL, Silverberg JI, Zippin J, Fonacier L, Tosti A, Lawley L, Chang MWu, Scheman A, Kleiner G, Williams J, Watsky K, Dunnick CA, Frederickson R, Matiz C, Chaney K, Estes TS, Botto N, Draper M, Kircik L, Lugo-Somolinos A, Machler B, Jacob SE
JournalDermatitis
Volume27
Issue5
Pagination293-302
Date Published2016 Sep-Oct
ISSN2162-5220
KeywordsAdolescent, Allergens, Bacitracin, Balsams, Betaine, Child, Child, Preschool, Cobalt, Dermatitis, Allergic Contact, Female, Formaldehyde, Gold, Humans, Infant, Infant, Newborn, Male, Neomycin, Nickel, Patch Tests, Perfume, Propylene Glycol, Registries, Retrospective Studies, United States
Abstract

BACKGROUND: Little is known about the epidemiology of allergic contact dermatitis (ACD) in US children. More widespread diagnostic confirmation through epicutaneous patch testing is needed.

OBJECTIVE: The aim was to quantify patch test results from providers evaluating US children.

METHODS: The study is a retrospective analysis of deidentified patch test results of children aged 18 years or younger, entered by participating providers in the Pediatric Contact Dermatitis Registry, during the first year of data collection (2015-2016).

RESULTS: One thousand one hundred forty-two cases from 34 US states, entered by 84 providers, were analyzed. Sixty-five percent of cases had one or more positive patch test (PPT), with 48% of cases having 1 or more relevant positive patch test (RPPT). The most common PPT allergens were nickel (22%), fragrance mix I (11%), cobalt (9.1%), balsam of Peru (8.4%), neomycin (7.2%), propylene glycol (6.8%), cocamidopropyl betaine (6.4%), bacitracin (6.2%), formaldehyde (5.7%), and gold (5.7%).

CONCLUSIONS: This US database provides multidisciplinary information on pediatric ACD, rates of PPT, and relevant RPPT reactions, validating the high rates of pediatric ACD previously reported in the literature. The registry database is the largest comprehensive collection of US-only pediatric patch test cases on which future research can be built. Continued collaboration between patients, health care providers, manufacturers, and policy makers is needed to decrease the most common allergens in pediatric consumer products.

DOI10.1097/DER.0000000000000214
Alternate JournalDermatitis
PubMed ID27649353