Submitted by anr2062 on April 2, 2019 - 9:23am
| Title | CO(2)/HCO(3)(-)-responsive soluble adenylyl cyclase as a putative metabolic sensor. |
| Publication Type | Journal Article |
| Year of Publication | 2001 |
| Authors | Zippin JH, Levin LR, Buck J |
| Journal | Trends Endocrinol Metab |
| Volume | 12 |
| Issue | 8 |
| Pagination | 366-70 |
| Date Published | 2001 Oct |
| ISSN | 1043-2760 |
| Keywords | Adenylyl Cyclases, Animals, Bicarbonates, Biological Evolution, Carbon Dioxide, Cyclic AMP, Homeostasis, Hydrogen-Ion Concentration, Metabolism, Signal Transduction, Solubility |
| Abstract | Cyclic AMP (cAMP) is an evolutionarily conserved regulator of metabolism. Recently, we identified a novel mammalian source of cAMP - soluble adenylyl cyclase (sAC) - that is regulated directly by bicarbonate ions (HCO(3)(-)). As the concentration of HCO(3)(-) reflects cellular levels of carbon dioxide (CO(2)), energy-generating metabolic processes (which increase intracellular CO(2)) are poised to activate bicarbonate-responsive sAC. This direct link between metabolic activity, sAC and cAMP could represent an evolutionarily conserved mechanism of metabolic feedback regulation. |
| Alternate Journal | Trends Endocrinol. Metab. |
| PubMed ID | 11551811 |
| Grant List | GM62328 / GM / NIGMS NIH HHS / United States HD38722 / HD / NICHD NIH HHS / United States HD42060 / HD / NICHD NIH HHS / United States |