Submitted by anr2062 on April 2, 2019 - 9:23am
| Title | Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain. |
| Publication Type | Journal Article |
| Year of Publication | 2004 |
| Authors | Zippin JH, Farrell J, Huron D, Kamenetsky M, Hess KC, Fischman DA, Levin LR, Buck J |
| Journal | J Cell Biol |
| Volume | 164 |
| Issue | 4 |
| Pagination | 527-34 |
| Date Published | 2004 Feb 16 |
| ISSN | 0021-9525 |
| Keywords | Adenylyl Cyclase Inhibitors, Adenylyl Cyclases, Animals, Bicarbonates, Cell Line, Cell Nucleus, Cercopithecus aethiops, Cyclic AMP, Cyclic AMP Response Element-Binding Protein, Cyclic AMP-Dependent Protein Kinases, Enzyme Activation, Gene Expression Regulation, Hepatocytes, Humans, Immunohistochemistry, Phosphorylation, Rats, Second Messenger Systems |
| Abstract | Bicarbonate-responsive "soluble" adenylyl cyclase resides, in part, inside the mammalian cell nucleus where it stimulates the activity of nuclear protein kinase A to phosphorylate the cAMP response element binding protein (CREB). The existence of this complete and functional, nuclear-localized cAMP pathway establishes that cAMP signals in intracellular microdomains and identifies an alternate pathway leading to CREB activation. |
| DOI | 10.1083/jcb.200311119 |
| Alternate Journal | J. Cell Biol. |
| PubMed ID | 14769862 |
| PubMed Central ID | PMC2172001 |
| Grant List | GM07739 / GM / NIGMS NIH HHS / United States R01 AR032147 / AR / NIAMS NIH HHS / United States HD38722 / HD / NICHD NIH HHS / United States R01 HD038722 / HD / NICHD NIH HHS / United States R01 GM062328 / GM / NIGMS NIH HHS / United States AR32147 / AR / NIAMS NIH HHS / United States HD42060 / HD / NICHD NIH HHS / United States T32 GM007739 / GM / NIGMS NIH HHS / United States GM62328 / GM / NIGMS NIH HHS / United States |